Liquisolid Compacts: A Review

Urvashi B. Patel, Dikshit C. Modi, Dhiren P. Shah


Solubility is a major problem for nearly one third drugs in their development phase. Liquisolid technique is a most promising technique for promoting dissolution by increase in solubility. Liquisolid compact technology is a novel concept for oral drug delivery. Liquisolid compact technology was first described by spireas (1998). According to the new formulation method of liqui-solid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients.


Solubility enhancement, Liquisolid Compact,

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. Spireas, S. Liqui-solid systems and methods of preparing same. U.S. Patent 6423339B1 (2002)

. Spireas, S., Sadu, S. Enhancement of prednisolone dissolution properties using liqui- Solid compacts. Int. J. Pharm. 1998; 166: 177-88.

. Yadav, V., Yadav, A., Bhise, S., Aceclofenac size enlargement by non aqueous granulation with improved solubility and dissolution. Arch. Pharm. Sci and Res. 2009: 1:115-122.

. Kulkarni Ajit S., Aloorkar Nagesh H., Mane Madhav S. and Gaja Jayashree B., Liqui-solid Systems. Int.J of Pharma. Sci. and Nanotechnology, 2010; 3(1):795-802.

. Bindu MB, Kusum B and David Banji, Novel Strategies for Poorly Water Soluble Drugs, International Journal Of Pharmaceutical Sciences Review and Research,2010; 4(3): 1-5.

. Sharma, A., Jain, C.P. Techniques to enhance solubility of poorly soluble drugs: a review. J. Global Pharm. Tech. 2010; 2: 18-28.

. Saharan. , Kukkar V., Kataria, M., Gera, M., Choudhury P., Dissolution enhancement of drugs. Part I: technologies and effect of carriers. Int. J. Health Res. 2009; 2: 107-124.

. Rakesh P. Patel, Jagrut H. Dhruv,Bnkimchandra J. Bhatt, Ajay. M. Suthar.Formulation development and optimization of Cefditoren pivoxil dispersible tablet, International Journal of Current Pharmaceutical Research, 2010; 2(1): 20-25.

. Ravi Kumar, Swati Patil M B Patil, Sachin R.Patil, Mahesh S. Paschapur. Formulation evaluation of mouth dissolving tablets of Fenofibrate using sublimation technique, Int J Chem Tech Res., 2009; 1(4): 840-850.

. Khattab, I., (1989) in The use of direct compression vehicles for the manufacture of certain medicinal tablets, Ph. M. Thesis, Faculty of pharmacy, Al- Azhar University, Cairo, Egypt.

. Spireas, S., Liquisolid systems and methods of preparing the same. Pharmaceutical patent, 6423339, July 23, (2002).



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