A Review of Association betweenEarly Exposure to Infant-feeding formulas and Type 1 Diabetes among Children

Yahaya T, Oladele, EO, Umar, J


The increasing incidenceof type 1 diabetes among children calls for a thorough understanding of the disease to stem its growth. Early exposure to infant-feeding formulas has been linked with the disease and several mechanisms of action have been proposed. However, it is unclear the exact mechanism by which infant-formulas aid in the pathogenesis of type 1 diabetes. This paper reviewed and articulated several hypotheses proposed as the mechanisms of action of infant formulas in the onset of type 1 diabetes. The Google search engine was used to search for relevant information on the internet from reputable sources such as PubMed, Google Scholar, among others.The majority of the studies reviewed overwhelmingly agreed early exposure to infant-feeding formulas may contribute to the pathogenesis of type 1 diabetes among children. Cow milk, for example, contains bovine insulin, which differs from human insulin with 3 amino acids, and can cause immune reactions in children. Gluten-containing diets such as wheat may cause proportional changes in immune cell populations or modify the cytokine/chemokine pattern towards an inflammatory profile. Concentrated soy-based formulas contain active estrogenic endocrine disruptors. Fruits, berries and roots may be infected with toxic antibiotics, which can start off autoimmunity. Nursing moms are therefore advised to breastfeedtheir babies for a long time before introducing infant-feeding formulas, especially those with a family with a history of diabetes.


Type 1 diabetes, Infant-feeding formulas, bovine insulin, Gluten, Pathogenesis

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. Artists Cooperative Groove Union, ACGU (2008). Food Causing Diabetes. http://www.13.waisays.com/diabetes.htm

. Knip M, Veijola R, Virtanen SM, Hyoty H, Vaarala O, Akerblom HK. Environmental triggers and determinants of ?-cell autoimmunity and type 1 diabetes. Diabetes, 2005; 54: S12536.

. National Institute of Diabetes and Digestive and Kidney Disease, NIDDK (2014). Causes of Diabetes.https://www.niddk.nih.gov/health-information/diabetes/causes

. Ziegler AG1, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA, 2003; 290(13): 1721-8.

. Kimpimaki T, Erkkola M, Korhonen S, et al. Short exclusive breast-feeding predisposes young children with increased genetic risk of type 1 diabetes to progressive beta-cell autoimmunity. Diabetologia, 2001; 44:639.

. Harjutsalo V, Sjoberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet, 2008; 371:177782.

. Patterson CC, Dahlquist GG, Gyrs E, Green A, Soltesz G. EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet, 2009; 373:202733.

. Morales, S (2017). Study Suggests Type 1 Risk Higher if You Give Infant This Baby Formula. Research and Product News for People with Diabetes. https://www.diabetesdaily.com/blog/study-suggests-type-1risk-higher-if-you-give-infant-this-baby-formula

. Harrison, L.C and Honeyman, MC. Cows milk and type 1 diabetes: The real debate is about mucosal immune function. Diabetes, 1999; 48(8):1501-1507.

. American Academy of Pediatrics Work Group, AAPWG. Infant feeding practices and their possible relationship to the etiology of diabetes mellitus. Pediatrics, 1994; 94(5):752-754.

. Vaarala, O. Is it dietary insulin? Ann N Y Acad Sci, 2006; 1079:350-9

. Makela, M.1, Vaarala, O., Hermann, R., Salminen, K., Vahlberg, T., Veijola. R. Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated. antibody response to dietary insulin. J Autoimmun, 2006; 27(1): 54-61.

. Founder, SJ (2012). Confirmed Anew: Cow Milk May Trigger Type 1 Diabetes http://www.greenmedinfo.com/blog/confirmed-anew-cows-milk-may-trigger-type-1-diabetes

. Diabetes Warrior, DW (2017). Baby Formula and Diabetes http://www.diabetes-warrior.net/2011/10/12/baby-formula-and-diabetes/

. Savilahti, E., Akerblom, H.K, Tainio V-M, Koskimies S. Children with newly diagnosed insulin dependent diabetes mellitus have increased levels of cow's milk antibodies. Diabetes Res, 1988; 7:13740.

. Luopajarvi, K., Savilahti, E., Virtanen SM, et al. Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood. Pediatr Diabetes, 2008; 9: 43441.

. Vaarala, O, Ilonen J, Ruohtula T, Pesola J, Virtanen SM, Harkonen T. Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study. Arch PediatrAdolesc Med, 2012; 166(7): 608-14.

. Clemente, M.G., De-Virgiliis, S., Kang, J.S., Macatagney, R., Musu, M.P., Di-Pierro, M.R., et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut, 2003; 52:218223.

. Day, L., Augustin, M.A., Batey, I., Wrigley, C.W. Wheat-gluten uses and industry needs. Trends Food Sci Tech., 2005; 17:8290.

. Edwards, N. M., Mulvaney, S.J., Scanlon, M.G and Dexter, J.E. Role of gluten and its components in determining durum semolina dough viscoelastic properties. Cereal Chem, 2003; 80:755763.

. Artur C and Ewa O. Role of gluten-free diet in pathogenesis of type 1 diabetes what new? Pediatric Endocrinology Diabetes and Metabolism, 2015; 4: 188-191.

. Chmiel R, Beyerlein A, Knopff A, Hummel S, Ziegler AG, Winkler C. Early infant feeding and risk of developing islet autoimmunity and type 1 diabetes. Acta Diabetol, 2015; 52(3): 621-4.

. Norris JM, Barriga K, Klingensmith G, Hoffman M, Eisenbarth GS, Erlich HA. Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA, 2003; 290 (13):1713-20.

. Frederiksen B, Kroehl M, Lamb MM, Seifert J, Barriga K, Eisenbarth GS, Infant exposures and development of type 1 diabetes mellitus: The Diabetes Autoimmunity Study in the Young (DAISY). JAMA Pediatr, 2013; 167 (9):808-15.

. Wahlberg J, Vaarala O, Ludvigsson J; ABIS-study group. Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children. Br J Nutr. 2006 Mar; 95(3):603-8

. Sildorf SM, Fredheim S, Svensson J, Buschard K. Remission without insulin therapy on gluten-free diet in a 6-year old boy with type 1 diabetes mellitus. BMJ Case Rep. 2012.

. Banin P, Perretta R, Ravaioli E, De Sanctis V. Regression of autoimmunity and abnormal glucose homeostasis in an adolescent boy with silent coeliac disease. Acta Paediatr, 2002; 91(10):1141-3.

. Ventura A, Neri E, Ughi C, Leopaldi A, Citt A, Not T. Gluten-dependent diabetes- related and thyroid-related autoantibodies in patients with celiac disease. J Pediatr, 2000; 137(2): 263-5

. Svensson J, Sildorf SM, Pipper CB, Kyvsgaard JN, Bjstrup J, Pociot FM. Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes: a pilot study. Springerplus, 2016; 5(1): 994.

. Danie, KT (2005). The Whole Soy Story: The Dark Side of America's Favorite Health Food. https://www.amazon.com/gp/product/0967089751?ie=UTF8&tag

. Price, WA (2010). Why Babies Should Not be Fed Soy. Weston A Price Foundation https://www.westonaprice.org/health-topics/soy-alert/why-babies-should-not-be-fed-soy/

. Shona, B (2011). Soy and soy products linked to type-1 diabetes and erectile dysfunction http://www.naturalnews.com/032141_soy_products_diabetes.html

. Strotmeyer ES, Yang Z, LaPorte RE, Chang YF, Steenkiste AR, Pietropaolo M. Infant diet and type 1 diabetes in China. Diabetes Res Clin Pract, 2004; 65 (3):283-92.

. Patisaul HB, Mabrey N, Adewale HB, Sullivan AW. Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats. Reprod Toxicol, 2014; 49: 209-18.

. Myers MA, Mackay IR and Zimmet PZ. Toxic type 1 diabetes. Rev Endocr Metab Disord, 2003; 4: 22531.

. Hettiarachchi KD, Zimmet PZ, Myers MA. Transplacental exposure to bafilomycin disrupts pancreatic islet organogenesis and accelerates diabetes onset in NOD mice. J Autoimmun, 2004; 22: 28796.

. Virtanen SM, Roivainen M, Andersson MA, et al. In vitro toxicity of cereulide on porcine pancreatic Langerhans islets. Toxicon, 2008; 51: 102937.

. Neale, T (2013). Diabetes Tied to Timing of Baby's First Solid Food. MEDPAGE TODAY. http://www.medpagetoday.com/pediatrics/parenting/40323

DOI: https://doi.org/10.7439/ijbar.v8i5.4047

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