Parasitemia and its relation to blood indices and liver function among malarial patients

Dr. Deepti Vivek Agnihotri, Khushbu Suryaprakash Soni

Abstract


Objectives: Objective of the study is to observe effects of Parasitemia on blood indices and liver function among malarial patients.

Material & Method: A total of 67 malarial patients attending the OPD were enrolled as test subjects. Venus blood was collected. Malarial parasite density was determined in various blood smears and analyzed for blood indices- Hb, PCV, total WBC, lymphocytes, neutrophils, platelets, AST, ALT, ALP, total and direct bilirubin.

Result & Discussion: There were significant decreases in the mean values of the hemoglobin (Hb), packed cell volume (PCV), total leucocyte counts (t WBC), lymphocytes and platelets. Neutrophils were significantly higher in patients with falciparum malaria in comparison to healthy subjects. There were significant increases in the mean activity enzyme values of AST, ALT, ALP and serum total and direct bilirubin. The present study reports a significant increase in neutrophil level of individuals infected with P falciparum as compared to healthy subjects.

Conclusion:  Haemoglobin, platelet count, lymphocyte level, total WBC and neutrophil level were seen associated with mild, moderate and severe parasitaemia infection. Acute falciparum malaria infection is associated with an increase in serum activity of aspartate and alanine aminotransferase and alkaline phosphatase thus indicating that the infection is associated with acute liver injury.


Keywords


Parasitemia,blood indices,liver fuction tests

Full Text:

PDF

References


. K Park, Park’s textbook of preventive and social medicine, Banarsidas Bhanot, Jabalpur, India, 21stedition, 2011.

. W.H.O., Guidelines for the treatment of malaria, world health organization, Geneva, Switzerland, 2nd edition, 2010.

. Abdulsalam M.Q.A.M, Mohammed A.K.M., Ahmed A. A, and Fong M.Y., Clinical situation of endemic malaria in Yemen. Tropical Biomedicine 2010; 27; 3: 551-558.

. Facer C.A., Haematological aspects of malaria in infection and hematology, Butterworth Heinemann, Oxford, UK, 1994.

. Maina, R.N. Waish D., Gaddy C, et al, Impact of plasmodium falciparum infection on haematological parameters in children living in western Kenya, Malaria Journal, 2010; l9 (3):s4.

. Chandra S. and Chandra H, Role of haematological parameters as an indicator of acute malarial infection in Uttarkhand state of India, Mediterranian Journal of Hematology and Infectious Diseases, 2013; 5 (1): e2013009.

. Price R.N., Simpson J.A., F. Nosten et al, Factors contributing to anemia after uncomplicated falciparum malaria, the American Journal of Tropical Medicine and Hygiene, 2004; 70 (1): 8-14.

. Erhart M., Yingyuen K., Nchuanak et al, Haematological and clinical indices of malaria in a semi immune population of western Thailand, American Journal of Tropical Medicine and Hygienevol 2004; 70 (1): 8-14.

. Burtis C., E Ashwood and B Border, liver functions in tietz Fundamentals of Clinical Chemistry, Saunders Company, Philadelphia, PA, USA, 5th edition 2001: 748-770.

. Onyesom I., Activities of some liver enzymes in serum of p falciparum malaria infected humans receiving artimisinin and non artimisinin based combination therapy, Annals of Biological Research, 2012; 3 (7): 3097-3100.

. Baheti R., Laddha P. and Gehlot R.S., Liver involvement in falciparum malaria a histo-pathological analysis, Journal, Indian Academy of Clinical Medicine, 2003; 4(1): 34-38.

. Harinasuta T. and Bunnag D, The clinical features of malaria in malaria: principles and practice of malariology, W.H. Wernsdorfer and I. A. McGregor, eds, Churchil Livingstone, Edinburgh, UK, 1988; 1: 709-732.

. W.H.O. Basic malaria microscopy; part I learner’s guide, World Health Organization Geneva, Switzerland, 1991.

. Bergmeyer H.U., Horder M. and Rej R, Approved recommendation on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2 IFCC method for aspartate aminotransferase. Journal of Clinical Chemistry and Clinical Biochemistry, 1986; 24:.497-510.

. ECCLS. Determination of catalytic activity concentration in serum of L-aspartate aminotransferase (EC 2.6.1.1, ASAT), Klinische Mitteilungen, 1989; 20: 198-204.

. Tietz N.W., Rinker A D and Shaw M., IFCC methods for the measurement of catalytic concentration of enzymes. 5. IFCC methods for alkaline phosphatise, Journal of Clinical Chemistry and Clinical Biochemistry, 1983; 21 (11): 731-748.

. Malloy H.T. and Evelyn K.A., The determination of bilirubin with the photoelectric colorimeter, The Journal of Biological Chemistry, 1937; 119: 481-490.

. Wahlefeld A.W., Herz G and Bernt E. Modification of Malloy Evelyn method for a simple reliable determination of total bilirubin in serum. Scandinavian Journal of Clinical and Lab Investigation, 1972; 29 Supplement 126: 11-12.

. George O.I. and Ewelike-ezeani C.S., Haematological changes in children with malaria infection in Nigeria. Journal of Medicine and Medical Sciences, 2011; 2 (4): 768-771.

. Nadeem M., Ali N, and Qamar M.A., Haematological findings in acute malarial infection list of authors along with highest qualification and institute, Biomedical, 2002; 18: 62-65.

. Goselle O.N., Onwuliri C.O.E. and Onwuliri V.A., Malaria infection in HIV/AIDS patients and its correlation with packed cell volume (PCV), Journal of Vector Borne Diseases, 2009; 46(3): 205-211.

. Bakhubaira S., Haematological parameters in severe complicated plasmodium falciparum malaria among adults in Aden, Turkish Journal of Hematology, 2013; 30(4): 394-399.

. Koltas I.S., Demirhindi H., Hazar S. and Ozcan K., Supportive presumptive diagnosis of plasmodium vivaxmalaria: thrombocytopenia and red cell distribution width, Saudi Medical Journal, 2007; 28(4): 535-539.

. Chandra S and Chandra H, Role of haematological parameters as an indicator of acute malarial infection in Uttarakhand state of India, Mediterranean Journal of Hematology and Infectious Diseases, 2000; 11(5): 277-299.

. Kayode O.T., Kayode A.A.A. and Awonuga O.O., Status of selected haematological and biochemical parameters in malaria and malaria typhoid coinfection, Journal of Biological Sciences, 2000; 13(2): 277-299.

. Wickramasinghe S.N. and Abdulla S.H., Blood and bone marrow changes in malaria, Best Practice And Research Clinica Hematology, 2000; 13(2): 277-299.

. Lathia T.B. and Joshi R., Can haematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics? Indian Journal of Medical Sciences, 2004; 58; 6: 239-244.

. Malik A.M., Zaffar N., Ali N., Malik A.M. and Khan R. Hematological findings and endemicity of malaria in gadapregion, Journal of the College of Physicians and Surgeons Pakistan, 2010; 20 (2): 112-116.

. Oyewole I, Senusie S. and Mansaray M, plasmodium falciparum-induced kidney and liver dysfunction in malaria patients in freetown, Sierraleone, Sierra Leone Journal of Biomedical Research, 2010; 2 (1): 70-74.

. Onyesom I and Onyemakonor N, Levels of parasitaemia and changes in some liver enzymes among malarial infected patients in edo-delta region of Nigeria, Current Research Journal of Biological Sciences, 2011; 3(2): 78-81.

. Ignatious C.M., Emeka E.N. and N.E. Blessing, Effect of malaria parasitaemia on liver enzyme tests, International Journal of Tropical Medicine, 2008; 3 (3): 49-52.

. Abro A.H., Ustadi A.M., Abro H.A., Abdou A.S., Younis N.J. and Akaila S.I., Jaundice with hepatic dysfunction in p. falciparum malaria, Journal of the College of Physicians and Surgeons Pakistan 2009; 19 (6): 363-366.

. Molyneux M.E., Looareesuwan S., Menzies I.S. et al, Reduced hepatic blood flow and intestinal malabsorption in severe falciparum malaria, The American Journal of Tropical Medicine and Hygiene, 1989; 40 (5): 470-476.

. Bhalla A., Suri V. and Singh V, Malarial Hepatopathy, Journal of Postgraduate Medicine, 2006; 52 (4): 315-320.

. Singh R, Kaur M. and Arora D.A., Prospective study of hepatic involvement in plasmodium falciparum malaria, Journal of Clinical and Diagnostic Research, 2010; 4 (2): 2190-2197.




DOI: http://dx.doi.org/10.7439/ijbar.v8i5.4151

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 International Journal of Biomedical and Advance Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.