A study of serum magnesium level in critically ill patients

Prasad G Ugaragol, L S Patil, L S Patil, L S Patil, Deepak Chinagi, Deepak Chinagi, Deepak Chinagi

Abstract


Background: It is considered that Hypomagnesemia is one of the underdiagnosed electrolyte abnormalities in patients who are critically ill. Many studies have been done to find the hypomagnesemia prevalence and its effects on patients regarding mortality and morbidity. So we have undertaken this study to know the effects of Hypomagnesemia in critically ill patients admitted in medical critical ward. And it is an observational study.

Aims and Objectives: To study the level of serum magnesium in critically ill patients and to correlate its effects with patient outcome in terms of length of stay in ICU, need for ventilator support, duration of ventilator support, APACHE II score. To detect any electrolyte abnormalities associated with hypomagnesemia.

Results: In our study, on admission in ICU, 55.3% patients had hypomagnesemia, and patients with hypomagnesemia have mean duration of stay in ICU was 8.2 days, longer duration on mechanical ventilator i.e. 6.3 day and APACHE II Score of 15.7 and more frequently patients were in sepsis (25.9%), 15.3 % had cardiovascular abnormality. Patients with hypomagnesemia were more frequently associated with Diabetes Mellitus (34%) and they were having higher mortality rate (48.9%).

Conclusion: In the critically ill patients Hypomagnesemia was prevalent in higher rate. And it was associated with a higher mortality rate in them. And the requirement of ventilator support and duration on ventilator was significantly higher in hypomagnesemic patients. Hypomagnesemia was more commonly associated with sepsis, diabetes mellitus. And also it was associated with higher mortality rates and APACHE II Score.


Keywords


Hypomagnesemia; Hypokalemia; APACHE II Score

Full Text:

PDF

References


. Bringhurst FR, Demay MB, Krane SM, Kronenberg HM. Bone and Mineral Metabolism in Health and Disease. In: Longo DL, Fauci AS, Kasper DL, HauserSL, Jameson JL, Loscalzo J, editors. Harrisons Principles of Internal Medicine.19th ed. New York: McGraw-Hill; 2012; 2461-63.

. Henk J. Huijgen, Marcel Soesan, Renata Sanders, et al. Magnesium Levels in Critically Ill Patients. Am J Clin Pathol 2000;114:688-695

. Ryzen E, Wagers PW, Singer FR,. Magnesium deficiency in a medical ICU population. Crit Care Med 1985; 13:19-21.

. Chernow B, Bamberger S, Stoiko M, et al. Hypomagnesemia in patients inpostoperative intensive care. Chest 1989; 95:391.

. Salem M, Kasinski N, Munoz R et al. Progressive magnesium deficiency increases mortality from endotoxin challenge: protective effects of acute magnesium replacement therapy. Crit Care Med 1995; 23:108-18.

. Safavi M, Honarmand A: Admission hypomagnesemia- impact on mortalityand morbidity in critically ill patients. Middle East J Anaesthesiol 2007; 19:645-60.

. Guerin C, Cousin C: Serum and erythrocyte magnesium in critically ill patients.Intensive Care Med 1996; 22:724-27.

. Rubeiz GJ, Thill-Baharozian M, Hardie D et al: Association of hypomagnesemia and mortality in acutely ill medical patients. Crit Care Med 1993; 21:203-09.

. Soliman HM, Mercan D et al: Development of ionized hypomagnesemia isassociated with higher mortality rates. Crit care med 2003; 31:1082-7.

. Huijgen HJ, Sanders R, Van Olden RW, et al. Intracellular and extracellular blood magnesium fractions in hemodialysis patients; is the ionized fraction a measure of magnesium excess. Clin Chem 1998;44:639-48.

. Fiaccordori E, delCanale S, Coffrini E et al: Muscle and serum magnesium inpulmonary intensive care unit patients. Crit Care Med 1988; 16:751-60.

. Tosiello L: Hypomagnesemia and diabetes mellitus a review of clinicalimplications. Arch Intern Med 1996;156:1143-8

. CS Limaye, VA Londhey, MY Nadkar, NE Borges. Hypomagnesemia incritically ill medical patients. J Assoc Physicians India. Jan 2011; 59:19-22.




DOI: https://doi.org/10.7439/ijbar.v8i12.4439



Copyright (c) 2017 International Journal of Biomedical and Advance Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.