The relationship between endometrial thickness and pregnancy rates in subfertil women underwent intrauterine insemination Following ovulation induction

Sawsan Khalil Said, Muhiy Chied Kadum Alkielabi


Objective: The aim of this study is the comparison of effects of Clomiphene Citrate (CC) & human menopausal Gonadotrophin (hMG) stimulated cycles on the Endometrial Thickness (ET) in intrauterine insemination (IUI) in one cycle & to establish any relation between ET on the day of IUI and achieving clinical pregnancy in these stimulated cycle.

Study design: A prospective observational study was undertaken for assessing effects of clomiphene citrate (CC) and human menopausal gonadotrophin hMG stimulated cycle on the ET and clinical pregnancy in single IUI cycle.

Subfertility cases were studied in two groups; Group A [ovulation induction (OI) with CC and IUI, n = 150] and Group B (OI with hMG and IUI, n = 150).

Results: Comparable data obtained in mean, age, duration of subfertility female, male (only oligo sperm a) in both group range of ET of clinical pregnancy in group A (n = 21) were 8.0 – 12.9 mm and 9.0 – 12.9 mm in group B (n = 40). (p value < 0.001) ongoing pregnancy beyond 1st trimester was higher in group B (n= 42) than group A (n = 19).

Conclusion: Mean ET and clinical pregnancy rate both were higher in hMG group compared to CC.


Infertility, intrauterine inseminations, endometrial thickness, pregnancy rate.

Full Text:




Botros, R. M. B. , RIZK. Juan, A. Garcia Velasco, Hassan, A. Sallam, antonis Makrig a NNakis. Cambridge. Infertility and assisted Reproduction. 2008:55

Burney, RO; Schust, DJ; Yaomum. Infertility in: Berek JS. 14eds Berek & Novak's Gynaecology Lippincott willams & Wilkins. 2007: 1185 1276.

Dieterich, C. increased endometrial thickness on the day iof hCG, injection dose not adversely affect pregnancy. Fertile steril 2002, 77: 781.

Noci 1- aging of the human endometrium. European obstetric. Gynecology reproductive biology 1995: 66: 181.

Gonen, Y. ; Casper, RF; Jacobson, W.; Blankier, J. , Endometrial thickness and growth during ovarian stimulation: a possible predictor of implantation in invitro fertilization. Fertile steril 1989: 52: 446-50.

Kovaes, P.; Matyas, S.; Boda, K.; Kaali, SG. , the effect of endometrial thickness on IVF/ICSI outcome. HUM Reprod 2003: 18: 2337-41.

Cunningham, FG. ; Leveno, KJ.; Bloom SL.; Hauth, JC.; Rouse, DJ.; Spong CY., from Williams obstetrics, USA Mc Graw Hill Companies: 2010. Figure 3-2, photomicrographs illustrating endometrial changes during menstrual cycle : p. 38.

Dodge, ST. ; Strick;er, RC. ; Keller, DW. , ovulation induction with low doses of clomiphene citrate. Obstet Gynecol. 1986; 67 : 635.

Verhulst, SM.; Cohlen, BJ.; Hughes, E.; Tevelde, E.; Heineman, MJ., international insemination for unexplained subfertility. Cochrane Database syst. Rev., 2006 ; 18: CD 001838.

Tomlinson, MJ. ; Amissah Arthur, JB.; Thompson, KA.; Kasraie, JL.; Bentick, B., prognostic indicators for intrauterine Insemination (IUI): statistical model of IUI success. Hum Reprod. 1996; 11: 1892-6.

Check, JH.; Davies, E.; Adelson, H. A randomized prospective study comparing pregnancy rates Following clomiphene citrate and human menopausal gonadotrophin therapy. Human Reprod. 1992 ; 7: 801-5.

Echochard, R.; Mathieu, C.; Royere, D.; Blache, G.; Rabilloud, M. ; Czyba, JC., A randomized prospective study comparing pregnancy rates after clomphene citrate and human menopausal gonodo trephine before intrauterine insemination. Fertil steril. 2000; 73: 90 3.

Coulan, CB.; Soenksen, DM.; Britten, S.; Ultra sono graphic pridictors of Implantation fertilsteril. 1994; 62 : 1004-10.

Schild, RL.; Eschweler, S.; Van Der Ven, H.; Fimmers, R.; Hansman, M., Three dimensional endometrial volum calculation and pregnancy rate in an in vitro fertilization programme. Hum Reprod, 1999; 14; 1255 8.

Kupesic, S.; Three dimensional ultrasonographic uterine vascularization and embryo implantation. J. Gynecol obstet Biol.Reprod. 2004; 33: 518 20.

Kasius etal. Human Reproduction update, vol. 20, No. 4. Pp 530 541 , 2014.

Kovacs, P. ; Matyas, SZ.; Boda, K.; Koali, SG., the effect of endometrial thickness on IVF/ICSI outcome. Human Reprod. 2003: 18: 2337-41.

Weissman, A.; Gotleib, L. ; Casper, Rf. , the detrimental effect of increased endometrial thickness on implantation and pregnancy rated and outcome in an in vitro ferlilization program. Fertile Steril,1999; 71; 81-3.

Rictoria Habib Zadeh, MD.; Sayed Noureddin Nematolahi Mahani, Ph. D.; Hadiss Kamyab, MD., the correlation of factors affecting the endometrial thickness with pregnancy outcome in the IUI cycles. Iranian Journal of Reproductive Medicine vol. 9, No. 1, pp: 41-46. Winter 2011.

Esmailzadeh, S., Endometrical thickness and pregnancy outcome after IUI. Fertility sterility 2007. 88:432-437.

Dickey, RP.; Olar, TT.; Taylor, SN.; Curok, DN.; Matulich, EM. Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of CC alone and with HMG. Fertility sterility 1993, 59: 756 760.


Copyright (c) 2018 International Journal of Biomedical and Advance Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.