Investigation of the Role of Single Nucleotide Polymorphisms (SNPs) in Premature Coronary Artery Disease

Qurratu Aini Musthafa, Zakiah Jubri, Mohd Zufri, Noor Akmal Shareela Ismail


Premature coronary artery disease is a concerning epidemic around the world. Therefore, there is a need to find useful biomarkers for a diagnostic tool to screen for the disease. This review aims to explore studies utilizing single nucleotide polymorphism (SNPs) to explain the heritable variation of bases in certain population that contribute to premature coronary artery disease. The studies have concluded the changes involved in lipid metabolism, oxidation of lipid and the significance of 9p locus. In recent years, many studies have done to reveal the gene-associated disease. The most robust genetic risk variant for CAD was identified on chromosome 9p21.3. This leads to the tremendous studies to explore the genetic variants underlie in the development of atherogenesis in early-onset CAD. Genome-wide association studies (GWAS) have enabled the discovery of 33 genetic risk variants for CAD by microarrays of SNPs. This includes 23 risk variants with unknown mechanism and only 10 associating with hypertension or lipids. This review will discuss on the association of SNPs studies with lipid metabolism, inflammation and oxidation.


Premature coronary artery disease; atherosclerosis; single nucleotide polymorphisms; risk allele; GWAS

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