A review- Recent research on microsponge a novel new drug delivery system

  • Urvashi B. Patel Ph.D Research Scholar, Department of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan-333001
  • Harshil M Patel Assistant Professor
  • Chainesh N. Shah Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat
  • Rohan Barse T. John College of Pharmacy, Bannergatta Road, Bangalore-560083
Keywords: Solubility Enhancement, Dissolution Rate, Novel Drug Delivery System, Immediate Release Drug Delivery

Abstract

Microsponge is recent novel technique for control release and target specific drug delivery system. Therefore many scientist or researcher attracted towards the microsponge drug delivery system. Also Microsponge technology has been introduced in topical drug products to facilitate the controlled release of active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active drugs. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Microsponge technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. In addition, numerous studies have confirmed that microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. Microsponge drug delivery system technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products.

Downloads

Download data is not yet available.

References

Gupta M, Goyal AK, Paliwal SR, Paliwal R, Mishra N, Vaidya B, Development and characterization of effective topical liposomal system for localized treatment of cutaneous candidiasis. J Liposome Res 2010; 20:341‑50.

Bidkar S, Jain D, Padsalg A, Patel K, Mokale V. Formulation development and evaluation of fluconazole gel in various polymer bases. Asian J Pharm 2007; 1:63‑8.

Schafer‑Korting M, Mehnert W, Korting HC. Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv Drug Deliv Rev 2007; 59: 427‑43.

Osmani RA, Aloorkar NH, Kulkarni AS, Harkare BR, Bhosale RR.A new cornucopia in topical drug delivery: Microsponge technology. Asian J Pharm Sci Tech 2014; 4:48‑60.

Teichmann A, Heuschkel S, Jacobi U, Presse G, Neubert RH, Sterry W, et al. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and anamphiphilic cream. Eur J Pharm Biopharm 2007; 67: 699‑706.

Pawar AP, Gholap AP, Kuchekar AB, Bothiraja C, Mali AJ. Formulation and evaluation of optimized oxybenzone microsponge gel for topical delivery. J Drug Deliv 2015; 2015: 261068.

Castro GA, Coelho AL, Oliveira CA, Mahecha GA, Oréfice RL, Ferreira LA. Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles. Int J Pharm 2009; 381:77‑83.

Bothiraja C, Gholap AD, Shaikh KS, Pawar AP. Investigation of ethyl cellulose microsponge gel for topical delivery of eberconazole nitrate for fungal therapy. Ther Deliv 2014; 5:781‑94.

Jadhav KR, Kadam VJ, Pisal SS. Formulation and evaluation of lecithin organogel for topical delivery of fluconazole. Curr Drug Deliv 2009; 6:174‑83.

Abdel‑Mottaleb MM, Mortada ND, El‑Shamy AA, Awad GA. Physically cross‑linked polyvinyl alcohol for the topical delivery of fluconazole. Drug Dev Ind Pharm 2009; 35:311‑20.

Yehia SA, El‑Gazayerly ON, Basalious EB. Fluconazole mucoadhesive buccal films: In-vitro/In-vivo performance. Curr Drug Deliv 2009; 6:17‑27.

Jelvehgari M, Siahi-Shadbad MR, Azarmi S, Gary P, Martin, Nokhodchi A. The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies. Int J Pharma 2006; 308:124-132.

Tansel C, Baykara T. The effects of pressure and direct compression on tabletting of microsponges. Int J Pharm 2002; 242: 191–95.

Martin A, Swarbrick J, Cammarrata A. In: Physical Pharmacy- Physical Chemical Principles in Pharmaceutical Sciences 1991; 3: 527.

Emanuele AD, Dinarvand R. Preparation, Characterization and drug release from thermo responsive microspheres. Int J Pharma 1995: 237-42.

Orr JRC. Application of mercury penetration to material analysis. Powder Technol. 1969; 3: 117–123.

Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y, Furuyama S. Characterization of polymorphs of tranilast anhydrate and tranilast monohydrate when crystallized by two solvent change spherical crystallization techniques. J Pharm Sci 1991; 81: 472-478.

Afrasim M. and Rohit R. Bhosale, Umme Hani, Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy, Journal of Basic and Clinical Pharmacy, 2016; 7(2): 39-46.

Barde P. and Basarkar G., Formulation, Development and In-vitro Evaluation of Terbinafine HCL Microscope Gel, Int. J. Pharm. Sci. Rev. Res., 2015; 32(1): 310-4.

Yadav P. and Nanda S., Development and evaluation of some microsponge loaded medicated topical formulations of acyclovir, IJPSR, 2014; 5(4): 1395-1410.

Ravi R., Senthil Kumar S.K., Parthiban S., Formulation and evaluation of the microsponges gel for an anti acne agent for the treatment of acne, Indian Journal of Pharmaceutical Science and Research, 2013; 3(1): 32-38.

Mohan K., Veena N, Manjula B P., Formulation and evaluation of microsponges for topical drug delivery of mupirocin, International Journal of Pharmtech Research, 2013; 5(3): 1434-1440.

Saboji, J. K.,1 Manvi, F. V., Gadad, A. P. and Patel, B. D., Formulation and evaluation of ketoconazole microsponge gel by quassi emulsion solvent diffusion, Journal Of Cell and Tissue Research, 2011; 11(1): 2691-2696.

Sabyasachi Maiti, Santanu K, Somasree B., Development and evaluation of xanthan gum-facilitated ethyl cellulose microsponges for controlled percutaneous delivery of diclofenac sodium, Acta Pharm. 2013; 61: 257–270

Netal A., Amrita B. and Madhu Madan, Development of microsponges for topical delivery of mupirocin, AAPS Pharmscitech, 2009; 10(2): 402-409.

Jain V. and Singh R, Development and Characterization of Eudragit RS 100 Loaded Microsponges and its Colonic Delivery Using Natural Polysaccharides. Acta Pol Pharm. 2010; 67(4): 407-15.

Mine O., Erdal C., Ahmet A., Design and Evaluation Of Colon Specific Drug Delivery system Containing Flurbiprofen Microsponges, International Journal of Pharmaceutics 2006; 318: 103–117.

Published
2018-03-31
How to Cite
1.
Patel U, Patel H, Shah C, Barse R. A review- Recent research on microsponge a novel new drug delivery system. IJAP [Internet]. 31Mar.2018 [cited 19Nov.2018];7(3):10-6. Available from: https://ssjournals.com.md-in-1.webhostbox.net/index.php/ijap/article/view/4838
Section
Review Article