Spectrophotometric Method for the Simultaneous Determination of Pseudoephedrine and Triprolidine in Bulk and Tablet Forms

  • Imad Osman Abu Reid Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al Ribat National University, Khartoum
  • Tasneem Awad Widaa Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al Ribat National University, Khartoum
Keywords: Spectrophotometry, Simultaneous, Triprolidine, Pseudoephedrine

Abstract

A spectrophotometric method was developed for the simultaneous determination of pseudoephedrine HCl (PSE) and triprolidine HCl (TRI) in bulk and dosage forms. The method involved the determination of pseudoephedrine in the presence of triprolidine using two wavelengths (257 nm & 290 nm). Beers law was obeyed in the concentration (152-760 ?g/ml) and (6.4-32 ?g/ml) with good linearity (0.9996 and 0.9996) for pseudoephedrine and triprolidine respectively. The accuracy and the precision of the developed method were very good (RSD ? 2%). The validity of the proposed method was confirmed through the statistical comparison of the obtained data with those of the official USP method.

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Published
2017-09-29
Section
Research Articles