Study of Effects of Consumption of Powdered Fenugreek Seeds on Serum Lipid Profile in Patients with Type 2 Diabetes Mellitus
Objectives: The aim of our study was to determine the role of fenugreek seed powder on serum lipid profile in patients of type 2 Diabetes Mellitus.
Methods: Of all the patients attending the medicine OPD of Muzaffarnagar Medical College & Hospital from June 2012 August 2014, 100 patients of Type II Diabetes Mellitus were selected randomly, including both male and female of age group 40-75 years. They were then divided into 2 groups, study group and control group. One group consisting of fifty patients was given only Anti-Diabetic treatment (control group) and another group consisting of fifty patients was given 50gm of powdered fenugreek seeds in two divided doses in their diet along with their Anti-Diabetic treatment (study group). All the hundred patients included in the study were on lifestyle modification also. Their serum fasting lipid profile levels were repeated every two months for a study period of six months and then the data from study and control group was evaluated and compared.
Results: There was significant reduction in total cholesterol, low density lipoprotein, very low density lipoprotein, and triglyceride and significant rise in the high density lipoprotein levels.
Conclusion: The result support the hypothesis and the research question that fenugreek supplement with usual medical care for Type II Diabetes Mellitus is more effective than the usual medical care alone. Therefore, it is recommended that fenugreek supplementation is safe and may be considered in Diabetic patients as a potential means to lower the serum lipid profile level.
Bhattaram V A, M Cerafe, C Kohlest, M Vest and H Deundorf. Pharmacokinetics and bioavailability of herbal medicinal products. Phytomed 2002; 9:1-36.
Abu Saleh M. Moosa etal. Effects of fenugreek on serum lipid profile in hypercholesteremic type 2 diabetes patients. Bangladesh J Pharmacol. 2006; 1:64-67.
Elder C. Ayurveda for diabetes mellitus: a review of the biomedical literature. Altern Ther Health Med 2004; 10: 44-50.
Tensen R. Fenugreek, overlooked but not forgotten. UCLA lactation Alumni Newsletter 1992; 1:2-3.
Jellin JM, Gregory PJ, etal. Pharmacists letter/prescribers Letter Natural Medicines comprehensive Database. 11th edition Stockton, California, therapeutic research faculty, 2009.
Raghuram TC, Sharma R, Sivakumar D, Sahay BK. Effect of fenugreek seeds on intravenous glucose disposition in Non-insulin dependent patients. Phytotherapy Res 1994; 8:83-86.
Prassana M. Hypoliidemic effect of fenugreek: a clinical study. Indian J Pharma 2000; 32:34-36.
Sauvaire Y etal. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secreation. Diabetes 1998; 47(2):206-210.
Lucy dey etal. Alternate therapies for type 2 diabetes. Altern Med Rev 2002; 7(1):45-58.
Bhaktha Geetha etal. Management of newly diagnosed type 2 diabetes by Fenugreek (Trigonella foenum-graecum). IJRAP 2011; 2( 4):1231-1234.
Evans AJ, Hood RL, Oakenfull DG and Sidhu GS. Relationship between structure and function of dietary fibre: a comparative study of the effects of three galactomannans on cholesterol metabolism in the rat. British journal of Nutrition 1992; 68:217-229.
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