Palonosetron A Promising New Prophylactic for PONV

  • Aashutosh R. Patel Department of Anaesthesiology, Indira Gandhi Government Medical College, C.A. Road, Nagpur, Maharashtra - 440018
  • Medha A. Sangawar Department of Anaesthesiology, Indira Gandhi Government Medical College, C.A. Road, Nagpur, Maharashtra - 440018
  • Vaishali C. Shelgaonkar Department of Anaesthesiology, Indira Gandhi Government Medical College, C.A. Road, Nagpur, Maharashtra - 440018
Keywords: PONV, palonosetron, ondansetron, antiemetic, nausea, vomiting


Aim and Objective- The aim of the study was to evaluate the efficacy of palonosetron 0.075 mg for prevention of postoperative nausea and vomiting (PONV) in patients undergoing middle ear surgeries in comparison with ondansetron.

Methods- In this prospective observational study, 70 healthy patients who were undergoing elective middle ear surgeries were divided into 2 groups: Group P (palonosetron 0.075 mg i.v., n = 35) and group C (ondansetron 8 mg i.v., n = 35). The drugs were given 5 minutes before induction of anaesthesia. The incidence of nausea, vomiting, retching, severity of nausea, use of recue antiemetic and incidence of complete response were evaluated.

Results- The incidence of nausea, vomiting and severity of nausea was lower in palonosetron group as compared to ondansetron group but this difference was not statistically different. The incidence of use of rescue antiemetic (5.71% vs 23.53%) was significantly lower in palonosetron group. The incidence of complete response was higher in palonosetron group (88.87% vs 68.57%) but the difference was not statistically significant.

Conclusion- The prophylactic intravenous administration of single dose of palonosetron 0.075 mg is not more effective in controlling postoperative nausea and vomiting as compared to ondansetron 8 mg in middle ear surgery.


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Honkavaara P. Effect of ondansetron on nausea and vomiting after middle ear surgery during general anaesthesia. British Journal of Anaesthesia. 1996, 76(2), 316-318.

Singh T, Shah N, Patel C and Upadhayaya RM. A comparative study of prophylactic ondansetron versus palonosetron for post operative nausea and vomiting in middle ear surgeries. International Journal of Biomedical and Advance Research. 2014, 05(12), 619-622.

Wallenborn J, Kranke P. Review - Palonosetron Hydrochloride in the prevention and Treatment of postoperative nausea and Vomiting. Clinical Medicine Insights: Therapeutics. 2010, 2, 387-399.

Wong EH, Clark R, Leung E, et al. The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. British Journal of Pharmacology. 1995, 114, 851-859.

Laha B, Hazra A, Mallick S. Evaluation of antiemetic effect of intravenous palonosetron versus intravenous ondansetron in laparoscopic cholecystectomy: a randomized controlled trial. Indian Journal of Pharmacology. 2013, 45(1), 24-29.

Elahl MI, Badea M. Palonosetron in preventing postoperative nausea and vomiting in middle ear surgery: A randomized-controlled study. The Egyptian Journal of Otolaryngology. 2013, 29(3), 156-158.

Candiotti KA, Kovac AL, Melson TI, Clerici G, Gan TJ. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomiting. Anesthesia & Analgesia. 2008, 107(2), 445-451.

Paventi S, Santevecchi A, Ranieri R. Efficacy of a single-dose ondansetron for preventing post-operative nausea and vomiting after laparoscopic cholecystectomy with sevoflurane and remifentanil infusion anaesthesia. European Review for Medical and Pharmacological Sciences. 2001, 5, 59-63.

Ahmed El-Hamid AM, Othman MSK, A? EE. Palonosetron versus ondansetron for prevention of postoperative nausea and vomiting during middle ear surgery: a double-blind, randomized, comparative trial. Ain-Shams J Anaesthesiol. 2014, 7(3), 309-313.

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