Can serum ionic magnesium disturbance increase the frequency of exacerbations in COPD? - A hospital based multi group case control study

  • Anand Agrawal Associate Professor & Head Department of Respiratory Medicine BPSGMC(W) Khanpur, Kalan Sonepat.
  • Himanshu Madaan Department of Biochemistry, KCMC Karnal
  • Chandermani . Junior Resident Department of Respiratory Medicine BPSGMCW Khanpur Kalan Sonepat.
Keywords: Chronic, Diseases, , Lung, Magnesium, Obstructive, Pulmonary

Abstract

Objectives: Hypomagnesaemia has been cited as a predictor of acute exacerbations of Bronchial asthma due to increased frequency of bronco spasm, though it is under explored in COPD, therefore present study designed to find out the association of disturbance in free serum ionic Mg2+ levels in acute exacerbation of COPD.

Methods: A case control hospital based multi-group study was designed. Total of 150 Study Subjects fit on inclusion criteria were included and comprises in three groups; G 1) Acute exacerbation of COPD (N=50); G 2) Healthy Controls (N=50); G 3) Known cases of COPD presenting to the OPD for follow up (N=50) to study the disturbance in serum ionic magnesium in patients of COPD with acute exacerbation. Data was analysed by using standard statistical software SPSS version 23. Chi Square, student t test and Pearson correlation and regression test were used as a tests of significance. p value < 0.05 was considered significant.

Results: Severe statistically significant diminution of serum ionic Mg2+ level was found in patients presented with an acute exacerbation of COPD (mean serum Mg2+=0.317mmol/l; SD0.06) compared to healthy (mean serum Mg2+=0.510mml/l; SD0.042) as well as stable COPD subjects (mean serum Mg2+=0.400 mmol/l; SD0.074; p=0.000). While mean serum ionic magnesium in type 2 Respiratory failure subjects was less than Non type 2 Respiratory failure (p=0.435). Serum ionic magnesium changes among subjects of COPD with acute exacerbation, was weakly associated with change in pH of blood (r = .057, p=0.697).

Conclusions: Diminution of serum ionic magnesium (iMg2+) concentration was significantly associated with acute exacerbation of COPD, as well as enhances the frequency of hospital admission.

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Author Biographies

Anand Agrawal, Associate Professor & Head Department of Respiratory Medicine BPSGMC(W) Khanpur, Kalan Sonepat.

Associate Professor & Head

Department of Respiratory Medicine

Himanshu Madaan, Department of Biochemistry, KCMC Karnal

Professor

Department of Biochemistry

KCMC Karnal.

Former

Associate Professor

Department of Biochemistry

BPSGMCW Khanpur Kalan Sonepat.

Chandermani ., Junior Resident Department of Respiratory Medicine BPSGMCW Khanpur Kalan Sonepat.

Junior Resident
Department of Respiratory Medicine
BPSGMCW Khanpur Kalan Sonepat.

Published
2017-09-30
Section
Original Research Articles