A study of cardiovascular abnormalities in newly diagnosed HIV infected children
Background: Children infected with HIV may develop a wide range of cardiovascular abnormalities, some of which are known to be associated with poor survival. With advances in the management of HIV patients, not only survival has increased but manifestations of late stage HIV infection are encountered more often including cardiovascular complications.
Aims: The present study was undertaken to determine the prevalence and nature of cardiovascular abnormalities in newly diagnosed HIV infected children.
Method: In this prospective, observational study, total 86 newly diagnosed HIV infected children, having age below 15 years and who were attending the PCOE at tertiary care institute were included in the study. All these recruited patients were subjected to chest radiograph, electrocardiography and 2D- echocardiography.
Results: There were six (7%) children with abnormal cardiovascular examination in form of tachycardia, tachypnea, increased precordial activity or murmur. Abnormal findings on chest radiograph were seen in 27 patients. Eight patients had right ventricular strain pattern and 3 patients had incomplete bundle branch block on electrocardiograph. On 2D echocardiography only 2 patients had thin rim of pericardial effusion. There was no significant correlation between these findings and clinical and immunological stage of patients. In patients with low CD4 counts or advanced stage there are higher chances of detecting a cardiovascular problem.
Conclusion: The study concluded that it is not cost effective to investigate for cardiovascular abnormalities in all newly diagnosed children at the onset. It can be done based on clinical examination, CD4 counts, stage of patients, and on follow up.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
- Author must Submit Copyright form After accepetance of Article.