Seroprevalance of ToRCH Infection –A Laboratory Profile

  • Anup Poudyal BP Koirala Institute of Health Sciences
  • Nimesh Poudyal BPKIHS
  • Basudha Khanal BPKIHS
Keywords: IgG, IgM, Pregnancy


Background: ToRCH infection (Toxoplasma gondii, Rubella virus, Cytomegalovirus, Herpes simplex virus) causes severe consequences in child in ongoing pregnancy. Screening for ToRCH etiologies are sought for those females who have had bad obstetrics history and in children born with birth defects. Such screening helps the couple and the clinicians to develop a consensus for preparedness of adverse fetal outcome, future prevention and planning for next conception.

Objectives: This retrospective study was conducted to have an understanding on the burden of ToRCH infection in various clinically suspected cases encountered in BPKIHS.

Methods:  Laboratory record of 52 serum samples submitted from August 2012 to July 2013 for screening of ToRCH infections was analyzed.

Result: Among 52 adult female serums, most (50) were positive for Cytomegalovirus (CMV) IgG, but none were reactive for Rubella IgM. Both IgG and IgM were positive for CMV in 10 cases, Herpes Simplex Virus (HSV) in 1 case and Toxoplasma in 1 case.

Conclusion: This study shows, CMV as the most common and Toxoplasma as the least common etiology among the ToRCH profile, in our setup.


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Author Biographies

Anup Poudyal, BP Koirala Institute of Health Sciences

Department of Microbiology

Assistant Professor

Nimesh Poudyal, BPKIHS

Associate Professor

Dept. of Microbiology

Basudha Khanal, BPKIHS


Dept. of Microbiology


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How to Cite
Poudyal A, Poudyal N, Khanal B. Seroprevalance of ToRCH Infection –A Laboratory Profile. IJBR [Internet]. 1May2018 [cited 14Dec.2018];9(4):154-7. Available from:
Original Research Articles

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