Study of urinary protein creatinine index in hypertensive patient
Objectives: Proteinuria is a hallmark of glomerular diseases. Uncontrolled high blood pressure increases the risk of glomerular disease leading to proteinuria and high urinary creatinine. So an attempt was made to validate the PCI of a random urine sample as a reliable and a convenient test.
Methods: Total of 42 hypertensive patients and 80 controls were selected. Their urinary protein was estimated by urinary dipstick method and colorimetric sulfosalicylic acid method. Urinary creatinine was estimated by modified Jaffe’s method. Protein creatinine index was measured for each patients and controls.
Results: It was found that the amount of creatinine in urine in hypertensive patients (0.91 ± 0.29 mmol/dl) was comparable to that in the control subjects (0.86 ± 0.38 mmol/dl).
The mean of urinary protein concentration in the hypertensive patients was 13.66 ± 5.77 mg/dl, and in the controls was 8.13 ± 2.82 mg/dl respectively. Highly significant value of PCI were observed in hypertensive patients (153 ±59.08) as compared to the controls where PCI was 114.64 ±47.96 (p<0.001).
Conclusion: PCI of a random urine sample can serve as a reliable and convenient test to replace 24 hr urine protein estimation. It can serve as baseline predictor of progression of renal diseases.
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