IN-VITRO STUDIES SUGGEST PROBABLE MECHANISM OF EUCALYPTUS OIL FOR ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY

  • Habibur Rahman Dept. Of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (dist.), Andhra Pradesh-508206, India
  • Chinna M Eswaraiah Dept. Of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (dist.), Andhra Pradesh-508206, India
  • Kamala Vakati Dept. Of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (dist.), Andhra Pradesh-508206, India
  • Madhavi P Dept. Of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (dist.), Andhra Pradesh-508206, India

Abstract

The present study aimed to study in-vitro anti-inflammatory and anti-arthritic activity of Eucalyptus globules oil. Anti-inflammatory activity of Eucalyptus globules oil at 100, 250, 500 mcg/ml were studied using human red blood cell membrane (HRBC) stabilization method and anti-arthritic activity of same concentration using bovine serum albumin denaturation(BSA) method. The effect Diclofenec and Aspirin at concentration of 100, 200 mcg/ml were also assessed as standard drug. Results showed significant ( 53.48%, 63.73% and 70.66% at 100, 250 and 500 mcg/ml of EGO) protection of HRBC and significant inhibition (16.98%, 58.49%, 66.03% at 100, 250 and 500 mcg/ml of EGO) in BSA denaturation and which are comparable to standard drugs diclofenec and aspirin. This result suggests about their potential action as anti-inflammatory and ant-arthritic activity and sets a platform for therapeutic use.

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Author Biographies

Habibur Rahman, Dept. Of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (dist.), Andhra Pradesh-508206, India
Asst. Professor, PhD Scholar, Dept. of Pharmacology
Chinna M Eswaraiah, Dept. Of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (dist.), Andhra Pradesh-508206, India
Prof. , Principal, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (dist.), Andhra Pradesh-508206, India
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Published
2012-07-01
How to Cite
1.
Rahman H, Eswaraiah C, Vakati K, P M. IN-VITRO STUDIES SUGGEST PROBABLE MECHANISM OF EUCALYPTUS OIL FOR ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY. IJPP [Internet]. 1Jul.2012 [cited 23Apr.2019];2(3):pp.81-3. Available from: https://ssjournals.com/index.php/ijpp/article/view/1142
Section
Research Articles