Investigation of cerebroprotective effect of Bixa orellana on sodium nitrite induced hypoxic neurotoxicity
The present study was carried out to evaluate the cerebroprotective effects of ethanolic extract of Bixa orellana leaves in hypoxic neurotoxicity induced rats. Hypoxia was induced by treatment of rats with sodium nitrite in drinking water for 30 days. Bixa orellana attenuated cognitive deficits in sodium nitrite induced rats which was studied by Morris water maze test. The extract restored the decreased levels of dopamine and increased levels of acetylcholinesterases and glutamate to the normal levels which can be compared with standard Pyritinol. The present study reveals that the ethanolic extract of Bixa orellana leaves confers cerebroprotection against sodium nitrite induced hypoxic neurotoxicity in rats.
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